Table 5.
CfmiRs that are commonly DE in MBM-01 and MBM-02 plasma samples compared to normal donors’ samples not present in the MBM tissues.
| Probe | FC MBM-01 vs. Normal |
Adjusted p-Value |
FC MBM-02 vs. Normal |
Adjusted p-Value |
|---|---|---|---|---|
| miR-6741-3p | 6.46 | 7.65 × 10−37 | 3.02 | 6.24 × 10−15 |
| miR-6852-3p | 5.34 | 2.41 × 10−22 | 4.9 | 7.63 × 10−26 |
| miR-4689 | 4.14 | 1.21 × 10−27 | 6.84 | 4.66 × 10−41 |
| miR-3943 | 3.56 | 6.57 × 10−21 | 3.01 | 2.44 × 10−21 |
| miR-541-3p | 3.34 | 8.31 × 10−18 | 1.56 | 7.64 × 10−4 |
| miR-3157-5p | 3.12 | 2.07 × 10−17 | 3.27 | 1.08 × 10−24 |
| miR-4784 | 2.44 | 1.27 × 10−13 | 1.73 | 3.33 × 10−7 |
| miR-4279 | 2.36 | 2.28 × 10−9 | 1.79 | 5.84 × 10−6 |
| miR-4664-3p | 2.17 | 1.96 × 10−10 | 4.31 | 7.29 × 10−24 |
| miR-4291 | 1.93 | 1.26 × 10−5 | 2.63 | 2.68 × 10−19 |
| miR-3912-5p | 1.88 | 7.34 × 10−7 | 1.71 | 1.14 × 10−7 |
| miR-5694 | 1.82 | 2.47 × 10−4 | 1.46 | 6.00 × 10−3 |
| miR-3912-3p | 1.79 | 1.35 × 10−5 | 1.57 | 4.39 × 10−5 |
| miR-670-3p | 1.78 | 3.53 × 10−5 | 2.66 | 3.32 × 10−22 |
| miR-4665-5p | 1.68 | 2.79 × 10−4 | 5.89 | 2.77 × 10−23 |
| miR-3937 | 1.67 | 1.10 × 10−3 | 2.98 | 3.76 × 10−8 |
DE = differentially expressed. CfmiRs = cell-free microRNAs. MBM-01 = melanoma brain metastasis first cohort. MBM-02 = melanoma brain metastasis second cohort. MBM = Melanoma brain metastasis. FC = fold-change.