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. 2020 Jun 19;21(12):4377. doi: 10.3390/ijms21124377

Figure 1.

Figure 1

CKD-581 is a potent HDAC inhibitor. (a) Acetylation of tubulin or histone H3. SU-DHL-2 cells were treated with vehicle control (C), CKD-581 (10–300 nM), or 300 nM SAHA (S) for 6 h, and total cell lysates were obtained. Acetylation of tubulin or histone H3 was determined by immunoblotting. (b) Comparison of inhibitory effects of CKD-581 and SAHA on cell viability of four DLBCL cell lines. SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells were incubated with CKD-581 and SAHA for 72 h, and cell viability was assessed by a CellTiter Bright-Glo assay. Data represent mean ± SEM (n = 3).