Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
UBQLNs and BCLb/BCL2L10 networking in cancers. BCLb stabilization increases the chance of BCLb-Bax binding leading to apoptosis reduction and cancer progression. Moreover, such a stabilization can increase the chance of BCLb to bind to BECN1. BCLb-BECN1 association causes a reduction of BCLb degradation and reduces autophagosome formation by disrupting BECN1-VPS34 complexes. The reduction of autophagy affects both cell death mechanism and chemo/radio sensitivity.
