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UBQLNs and insulin-like growth factor 1 receptor (IGF1R) networking in cancers. The stabilization of UBQLN1 and IGF1R can be found in various forms such as pro-form, phosphorylated form and normal form. After IGF1R activation, downstream signal transduction pathways including RAS/MAPK, JAK/STAT and PI3K/AKT, are activated to drive cancer progression.
