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Different agents trigger (after a priming process) the activation of the NLRP3 inflammasome-IL-1β pathway to promote atherosclerosis. ASC, apoptosis-associated speck-like protein containing a caspase recruitment; ATP, adenosine triphosphate; CARD, caspase recruitment domain–containing protein; IL-1β, interleukin IL-1β; IL-6, interleukin 6; LRR, leucine-rich repeats; ROS, reactive oxygen radicals; TLR, Toll-like receptor.
