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. 2020 Jun 8;12(6):1491. doi: 10.3390/cancers12061491

Figure 6.

Figure 6

Analysis of the activation of hepatic immune infiltrates during HCC development on NASH background. Diabetic (STZ) C57Bl6/J male mice were fed either a SD, a HFHCD or a HFHSD during 1, 4 and 8 weeks. Percentages of activated CD4+ T cells (Activated LT4), CD8+ T cells (Activated LT8), regulatory T cells (Activated LTreg), B cells (Activated LB) and Natural Killer (Activated NK) cells. For all graph, each black dots, black squares and black triangles represent individuals from the different groups: diabetic mice under SD, diabetic mice under HFHCD or HFHSD, respectively. ## p < 0.01 and ### p < 0.001 compared diabetic mice under SD to healthy mice under SD; $ p < 0.05; $$ p < 0.01 and $$$ p < 0.001 compared diabetic mice under HFHCD or HFHSD to diabetic mice under SD; * p < 0.05; ** p < 0.01 and *** p < 0.001 compared diabetic mice under HFHCD to diabetic mice under HFHSD at same time point.