Table 1.
Demographics and clinicopathological characteristics of pancreatic ductal adenocarcinoma patients and healthy controls used in the training and validation sets.
| Pancreatic Ductal Adenocarcinoma | |||||
|---|---|---|---|---|---|
| Total | Training set | Validation set | p-value | ||
| n = 180 | n = 120 | n = 60 | |||
| Age | 64.4 (9.8) | 63.6 (9.9) | 66.0 (9.5) | 0.109 | |
| Sex | M | 117 (65.0) | 75 (62.5) | 42 (70) | 0.320 |
| F | 63 (35.0) | 45 (37.5) | 18 (30) | ||
| Operation | PPPD | 62 (34.4) | 44 (36.7) | 18 (30) | 0.996 |
| PD | 38 (21.1) | 25 (20.8) | 13 (21.7) | ||
| DP | 50 (27.8) | 32 (26.7) | 18 (30) | ||
| TP | 15 (8.3) | 11 (9.2) | 4 (6.7) | ||
| Others * | 15 (8.3) | 8 (6.7) | 7 (11.7) | ||
| Stage | 1 | 53 (29.4) | 35 (29.2) | 18 (30) | 0.996 |
| 2 | 74 (41.1) | 50 (41.7) | 24 (40) | ||
| 3 | 30 (16.7) | 20 (16.7) | 10 (16.7) | ||
| 4 | 23 (12.8) | 15 (12.5) | 8 (13.3) | ||
| T stage | 1 | 22 (12.2) | 13 (10.8) | 9 (15.0) | 0.711 |
| 2 | 94 (52.2) | 66 (55.0) | 28 (46.7) | ||
| 3 | 38 (21.1) | 26 (21.7) | 12 (20.0) | ||
| 4 | 10 (5.6) | 6 (5.0) | 4 (6.7) | ||
| NA | 16 (8.9) | 9 (7.5) | 7 (11.7) | 0.779 | |
| N stage | 0 | 69 (38.3) | 47 (39.2) | 22 (36.7) | |
| 1 | 73 (40.6) | 47 (39.2) | 26 (43.3) | ||
| 2 | 26 (14.4) | 19 (15.8) | 7 (11.7) | ||
| NA | 12 (6.7) | 7 (5.8) | 5 (8.3) | ||
| Differentiation | WD | 14 (7.8) | 9 (7.5) | 5 (8.3) | 0.862 |
| MD | 118 (65.6) | 80 (66.7) | 38 (63.3) | ||
| PD | 26 (14.4) | 18 (15.0) | 8 (13.3) | ||
| NA | 22 (12.2) | 13 (10.8) | 9 (15.0) | ||
| Lymphatic | No | 78 (43.3) | 52 (43.3) | 26 (43.3) | 0.948 |
| invasion | Yes | 77 (42.8) | 52 (43.3) | 25 (41.7) | |
| NA | 25 (13.9) | 16 (13.3) | 9 (15.0) | ||
| Venous | No | 61 (33.9) | 41 (34.2) | 20 (33.3) | 0.575 |
| invasion | Yes | 85 (47.2) | 54 (45.0) | 31 (51.7) | |
| NA | 34 (18.9) | 25 (20.8) | 9 (15.0) | ||
| Perineural | No | 19 (10.6) | 14 (11.7) | 5 (8.3) | 0.547 |
| invasion | Yes | 145 (80.6) | 97 (80.8) | 48 (80.0) | 0.547 |
| NA | 16 (8.9) | 9 (7.5) | 7 (11.7) | ||
| Healthy control | |||||
| Total | Training set | Validation set | p-value | ||
| n = 573 | n = 382 | n = 191 | |||
| Age | 56.9 (8.8) | 56.6 (8.9) | 57.5 (8.6) | 0.250 | |
| Sex | M | 334 (58.3) | 218 (57.1) | 116 (60.7) | 0.420 |
| F | 239 (41.7) | 164 (42.9) | 75 (39.3) | ||
PPPD, pylorus-preserving pancreaticoduodenectomy; PD, pancreaticoduodenectomy; DP, distal pancreatectomy; TP, total pancreatectomy; NA, not available; WD, well-differentiated; MD, moderated differentiated; PD, poorly differentiated; * Others, bypass surgery and open biopsy.