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. 2020 Jun 12;12(6):1555. doi: 10.3390/cancers12061555

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of proteins differentially expressed between exosomes, derived from RBT and RBVS of the same patient. (A) Venn diagram of the total number of detected proteins in RBT1 and RBVS1-derived exosomes. Notably, 187 proteins were exclusively present in RBT1-derived exosomes, while 77 proteins were exclusively present in RBVS1-derived exosomes. Overall, 1395 proteins were shared by the two cell lines. (B) The volcano plot illustrates the results of data obtained from the two different conditions, RBT1 and RBVS1. The proteomes are compared, starting from a value of FDR < 0.05 and S0 > 0.1. Density plot coloration highlights the similarity between the two groups, black dots are the proteins that exceed the acceptability threshold, significantly modulated. (C) Graphical representation of the molecular function and biological processes for common exosomal proteins of RBT1 and RBVS1 obtained with FunRich software. (D) Graphical representation of molecular function gene enrichment for RBT1 and RBVS1 exclusive proteins. (E) Graphical representation of biological processes gene enrichment for RBT1 and RBVS1 exclusive proteins.