Table 1.
Name, cellular location and function of proteins exclusively present in RBT derived exosomes.
| Protein ID | Protein Name | Gene Name | Location | Function |
|---|---|---|---|---|
| Q9NYB9 | Abl interactor 2 | ABI2 | Cytoplasm | Binding |
| E9PHN7 | Glutathione S-transferase Mu 1; Glutathione S-transferase Mu 2 | GSTM1; GSTM2; GSTM4 | Cytoplasm | amine binding activity |
| O14594 | Neurocan core protein | NCAN | Extracellular Region or Secreted | Binding |
| P21283 | V-type proton ATPase subunit C 1 | ATP6V1C1 | Cytoplasm | active transmembrane transporter activity |
| P60880 | Synaptosomal-associated protein 25 | SNAP25 | Plasma Membrane | Binding |
| P63151 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | PPP2R2A; PPP2R2D | Cytoplasm | catalytic activity |
| Q92575 | UBX domain-containing protein 4 | UBXN4 | Nucleus and Endoplasmatic Reticulum | Involved in endoplasmic reticulum-associated protein degradation |
| O75970-5 | Multiple PDZ domain protein | MPDZ | Plasma Membrane | Binding |
| F8W1A4 | Adenylate kinase 2, mitochondrial; Adenylate kinase 2, mitochondrial, N-terminally processed | AK2 | Mitochondrial Intermembrane Space | adenyl nucleotide binding |
| G3V461 | CREATINE Kinase B-type | CKB | Cytosol | adenyl nucleotide binding |
| P41567 | Eukaryotic translation initiation factor 1 | EIF1 | Nucleus | Binding |
| O15144 | Actin-related protein 2/3 complex subunit 2 | ARPC2 | Cytosol | structural constituent of cytoskeleton |
| Q13554-3 | Calcium/calmodulin-dependent protein kinase type II subunit beta | CAMK2B | Cytoskeleton | adenyl nucleotide binding |
| Q15054-3 | DNA polymerase delta subunit 3 | POLD3 | Nucleus | catalytic activity |
| Q70UQ0 | Inhibitor of nuclear factor kappa-B kinase-interacting protein | IKBIP | Endoplasmatic Reticulum | Target of p53/TP53 with pro-apoptotic function. |
| Q8TDM6 | Disks large homolog 5 | DLG5 | Plasma Membrane | binding |
| Q96D05-2 | Uncharacterized protein C10orf35 | C10orf35 | Membrane | |
| Q9C040 | Tripartite motif-containing protein 2 | TRIM2 | Cytoplasm | transferase |
| Q9H3Z4 | DNA J homolog subfamily C member 5 | DNAJC5 | Plasma Membrane | ATP-dependent protein binding |
| Q9UJS0-2 | Calcium-binding mitochondrial carrier protein Aralar2 | SLC25A13 | Mitochondrion | transport |
| Q9Y2Q0-3 | Phospholipid-transporting ATPase IA | ATP8A1 | Golgi Apparatus, Plasma Membrane, Endoplasmatic Reticulum | translocase |
| A0A0A0MTB8 | WD repeat-containing protein 36 | WDR36 | Nucleus | rRNA processing |
| B1AM27 | Protein unc-13 homolog B | UNC13B | NA | binding |
| A0A2R8Y6W8 | TFIIH basal transcription factor complex helicase XPB subunit | ERCC3 | NA | binding |
| A0A3B3IRW6 | Glutamine and serine-rich protein 1 | QSER1 | NA | NA |
| A6PVN5 | Serine/threonine-protein phosphatase 2A activator | DKFZp781M17165; PPP2R4 | Cytoplasm | isomerase, rotamase |
| H0Y9M8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | NDUFS4 | NA | catalytic activity |
| H3BV16 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | NDUFB10 | NA | catalytic activity |
| K7EKE6 | Lon protease homolog, mitochondrial | LONP1 | Mitochondrion | adenyl nucleotide binding |
| M0QXF7 | Myeloid-derived growth factor | MYDGF | ||
| P27707 | Deoxycytidine kinase | DCK | Nucleous | kinase transferase |
| P30154-4 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | PPP2R1B | Extracellular Region Or Secreted | protein phosphatase regulator activity |
| P35754 | Glutaredoxin-1 | GLRX | Cytoplasm | binding |
| P41236 | Protein phosphatase inhibitor 2; Protein phosphatase inhibitor 2-like protein 3 | PPP1R2; PPP1R2P3 | protein phosphatase activity | |
| P47985 | Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit Rieske, mitochondrial; Putative cytochrome b-c1 complex subunit Rieske-like protein 1 | UQCRFS1; UQCRFS1P1 | Mitochondrion | translocase |
| Q00013-2 | 55 kDa erythrocyte membrane protein | MPP1 | Plasma Membrane | guanylate kinase activity |
| Q01814-6 | Plasma membrane calcium-transporting ATPase 2 | ATP2B2 | Plasma Membrane | active transmembrane transporter activity |
| Q12907 | Vesicular integral-membrane protein VIP36 | LMAN2 | Golgi Apparatus, Endoplasmatic Reticulum | binding |
| Q13432 | Protein unc-119 homolog A | UNC119 | Cytoskeleton | binding |
| Q13614 | Myotubularin-related protein 2 | MTMR2 | Endosome | catalytic activity, binding |
| Q15121 | Astrocytic phosphoprotein PEA-15 | PEA15 | Cytoplasm | apoptosis, transport |
| Q16720-4 | Plasma membrane calcium-transporting ATPase 3 | ATP2B3 | Plasma Membrane | active transmembrane transporter activity |
| Q6GMV3 | Putative peptidyl-tRNA hydrolase PTRHD1 | PTRHD1 | hydrolase | |
| Q6P1M0 | Long-chain fatty acid transport protein 4 | SLC27A4 | Endoplasmatic Reticulum | binding |
| Q8N5M4 | Tetratricopeptide repeat protein 9C | TTC9C | NA | NA |
| Q8NG11-2 | Tetraspanin; Tetraspanin-14 | TSPAN14 | Plasma Membrane | enzyme binding |
| Q8TF74 | WAS/WASL-interacting protein family member 2 | WIPF2 | Cytoskeleton | actin filament binding |
| Q92600 | Cell differentiation protein RCD1 homolog | RQCD1 | Nucleus | binding |
| Q92604 | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 | LPGAT1 | Endoplasmatic Reticulum | catalytic activity; transferase activity |
| Q92784-2 | Zinc finger protein DPF3 | DPF3 | Nucleus | binding |
| Q96G46 | tRNA-dihydrouridine(47)synthase [NAD (P)(+)]-like | DUS3L | NA | binding |
| Q9BXS6-4 | Nucleolar and spindle-associated protein 1 | NUSAP1 | Nucleus, Cytoskeleton | binding |
| Q9NPJ6 | Mediator of RNA polymerase II transcription subunit 4 | MED4 | Nucleus | binding |
| Q9Y237 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 | PIN4 | Nuclous, Mitocondrion | binding |
| A0A075B754 | ATPase family AAA domain-containing protein 5 | ATAD5 | NA | ATP binding |
| A0A087 × 0U3 | Amino acid transporter; Excitatory amino acid transporter 1 | SLC1A3 | Membrane | Symporter activity |
| A0A0A6YYL4 | Coronin; Coronin-7 | CORO7; CORO7-PAM16 | Golgi Apparatus | NA |
| Q9NY35-2 | Claudin domain-containing protein 1 | CLDND1 | Membrane | NA |
| A0A2R8YDI1 | Homeobox protein cut-like 1; Protein CASP | CUX1 | Nucleus | DNA binding |
| A0MZ66-8 | Shootin-1 | KIAA1598 | Cytoskeleton | binding |
| A6NKD9 | Coiled-coil domain-containing protein 85C | CCDC85C | Tight Junction, Adherens Junction | Developmental protein |
| B4DY26 | Receptor protein serine/threonine kinase; TGF-beta receptor type-1 | TGFBR1 | Plasma Membrane | binding |
| B7ZAQ6-2 | Golgi pH regulator A; Golgi pH regulator B | GPR89A; GPR89B | Golgi Apparatus | anion channel activity |
| C9JVC9 | Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2 | CACNA2D2 | NA | binding |
| E7EQM8 | Netrin receptor DCC | DCC | Membrane | netrin receptor activity |
| H0Y6H0 | Lysine-specific histone demethylase 1B | KDM1B | NA | binding |
| O43759-2 | Synaptogyrin-1 | SYNGR1 | Membrane | NA |
| O60911 | Cathepsin L2 | CTSV | Lysosome | aminopeptidase activity |
| O75182-2 | Paired amphipathic helix protein Sin3b | SIN3B | Nucleus | binding |
| O75380 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | NDUFS6 | Mitochondrion | catalytic activity |
| O94888 | UBX domain-containing protein 7 | UBXN7 | Nucleus | binding |
| O95049-5 | Tight junction protein ZO-3 | TJP3 | Nucleus Plasma Membrane | NA |
| P07196 | Neurofilament light polypeptide | NEFL | Cytosol, Cytoskeleton | binding |
| P11908 | Ribose-phosphate pyrophosphokinase 2 | PRPS1; PRPS2 | Cytoplasm | adenyl nucleotide binding |
| P14635 | G2/mitotic-specific cyclin-B1 | CCNB1 | Nucleus, Cytoskeleton | binding |
| P21912 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | SDHB | Mitochondrion | binding |
| P30405 | Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase F, mitochondrial | PPIF | Mitochondrion | binding |
| P56211 | cAMP-regulated phosphoprotein 19 | ARPP19 | Cytoplasm | binding |
| P60468 | Protein transport protein Sec61 subunit beta | SEC61B | Endoplasmic Reticulum | binding |
| Q13153 | Non-specific serine/threonine protein kinase; Serine/threonine-protein kinase PAK 1 | PAK1 | Nucleus Plasma Membrane | adenyl nucleotide binding |
| Q13438-6 | Protein OS-9 | OS9 | Endoplasmic Reticulum | binding |
| Q14118 | Alpha-dystroglycan;Beta-dystroglycan; Dystroglycan | DAG1 | Nucleus, Cytoskeleton, Extracellular Region, Plasma Membrane | actin binding |
| Q15811 | Intersectin-1 | ITSN1 | Nucleus, Endosome, Plasma Membrane | binding |
| Q53EL6 | Programmed cell death protein 4 | PDCD4 | Nucleus | nucleic acid binding |
| Q5T5Y3-2 | Calmodulin-regulated spectrin-associated protein 1 | CAMSAP1 | Cytoskeleton | binding |
| Q68CZ6 | HAUS augmin-like complex subunit 3 | HAUS3 | Cytoskeleton | cell division |
| Q86T03-2 | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase | TMEM55B | Plasma Membrane, Endosome, Lysosome | catalytic activity |
| Q8N201 | Integrator complex subunit 1 | INTS1 | Nucleus | snRNA processing |
| Q8N5K1 | CDGSH iron-sulfur domain-containing protein 2 | CISD2 | Mitochondrion, Endoplasmic Reticulum | 2 iron, 2 sulfur cluster binding |
| Q92752 | Tenascin-R | TNR | Extracellular Region or Secreted | cell adhesion |
| Q9BW30 | Tubulin polymerization-promoting protein family member 3 | TPPP3 | Cytoskeleton | tubulin binding |
| Q9BZH6 | WD repeat-containing protein 11 | WDR11 | Nucleus, Cytoskeleton, Golgi Apparatus | protein transport |
| Q9NUQ9-2 | Protein FAM49B | FAM49B | Membrane | platelet degranulation, regulation of T cells |
| Q9NXG6 | Transmembrane prolyl 4-hydroxylase | P4HTM | Endoplasmic Reticulum | binding |
| Q9NZB2 | Constitutive coactivator of PPAR-gamma-like protein 1 | FAM120A | Plasma Membrane | RNA binding |
| Q9UEY8-2 | Gamma-adducin | ADD3 | Cytoskeleton, Plasma Membrane | structural constituent of cytoskeleton |
| Q9UJA5 | tRNA (adenine(58)–N(1))-methyltransferase non-catalytic subunit TRM6 | TRMT6 | Nucleus | RNA binding |
| Q9UKX7-2 | Nuclear pore complex protein Nup50 | NUP50 | Nucleus | transport |
| Q9Y277 | Voltage-dependent anion-selective channel protein 3 | VDAC3 | Mitochondrion | transport |