Table 2.
Name, cellular location and function of proteins exclusively present in RBVS derived exosomes.
| Protein ID | Protein Name | Gene Name | Location | Function |
|---|---|---|---|---|
| P20774 | Mimecan | OGN | Extracellular region or Secreted | growth factor activity |
| Q07954 | Prolow-density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1, 85 kDa subunit; Low-density lipoprotein receptor-related protein 1, 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain | LRP1 | Plasma membrane and Nucleous | Developmental Protein, Receptor |
| P49747 | Cartilage oligomeric matrix protein | COMP | Extracellular region or Secreted | Binding |
| P05106 | Integrin beta-3; Integrin beta | ITGB3 | Plasma membrane | Cell adhesion, binding |
| Q5GLZ8-3 | Probable E3 ubiquitin-protein ligase HERC4 | HERC4 | Cytosol | Transferase |
| Q8NHG7 | Small VCP/p97-interacting protein | SVIP | Golgi apparatus, Plasma membrane, Endoplasmic reticulum | ATPase binding |
| Q92626 | Peroxidasin homolog | PXDN | Extracellular region or Secreted | Oxidoreductase, Peroxidase |
| P23352 | Anosmin-1 | KAL1 | Extracellular region or Secreted | binding |
| Q15582 | Transforming growth factor-beta-induced protein ig-h3 | TGFBI | Extracellular region or Secreted | binding |
| P30043 | Flavin reductase (NADPH) | BLVRB | Cytoplasm | Oxidoreductase |
| A0A0J9YWJ4 | RNA polymerase II subunit A C-terminal domain phosphatase | CTDP1 | Nucleus | RNA polymerase |
| P48740-2 | Mannan-binding lectin serine protease 1; Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain | MASP1 | Extracellular region or Secreted | binding |
| Q9Y6C2 | EMILIN-1 | EMILIN1 | Extracellular region or Secreted | Structural molecule activity |
| P13929-3 | Beta-enolase; Enolase | ENO3 | Cytoplasm | Binding |
| Q93063 | Exostosin-2 | EXT2 | Endoplasmic reticulum, Golgi apparatus | binding, Catalytic activity |
| Q15113 | Procollagen C-endopeptidase enhancer 1 | PCOLCE | Extracellular region or Secreted | binding |
| P04114 | Apolipoprotein B-100; Apolipoprotein B-48 | APOB | Extracellular region or Secreted | binding |
| Q92793 | CREB-binding protein | CREBBP | Nucleus | Acetyltransferase activity |
| S4R3D5 | Aldo-keto reductase family 1 member C2; Aldo-keto reductase family 1 member C1; Aldo-keto reductase family 1 member C3; Aldo-keto reductase family 1 member C4 | AKR1C3;AKR1C2;AKR1C1;AKR1C4 | NA | Oxidoreductase activity |
| Q05397-5 | Focal adhesion kinase 1 | PTK2 | Nucleus, Cytoskeleton, Plasma membrane | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
| B4DNG0 | Olfactomedin-like protein 3 | OLFML3 | NA | NA |
| E9PGA6 | Complement C1q tumor necrosis factor-related protein 3 | C1QTNF3-AMACR; C1QTNF3 | Extracellular region or Secreted | NA |
| Q8N8E3 | Centrosomal protein of 112 kDa | CEP112 | Cytoskeleton | Receptor localization to synapse |
| O43829 | Zinc finger and BTB domain-containing protein 14 | ZBTB14 | Nucleus | DNA binding |
| O95084 | Serine protease 23 | PRSS23 | Extracellular region or Secreted | Hydrolase, Protease, Serine protease |
| P08493 | Matrix Gla protein | MGP | Extracellular region or Secreted | Developmental protein |
| Q5SVZ6 | Zinc finger MYM-type protein 1 | ZMYM1 | Nucleus | binding |
| Q709F0-3 | Acyl-CoA dehydrogenase family member 11 | ACAD11 | Peroxisome, Mitochondrion | acyl-CoA dehydrogenase activity, Binding |
| Q9BT92 | Trichoplein keratin filament-binding protein | TCHP | Mitochondrion, Plasma membrane, Cytoskeleton | Apoptosis, Cilium biogenesis/degradation |
| Q9NRF9 | DNA polymerase epsilon subunit 3 | POLE3 | Nucleus | DNA binding |