Table 1.
Characteristics of the patients.
| Clinical and Demographic Features | All Patients | RT + CHT | RT Alone | p a |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| Total | 422 (100) | 203 (100) | 219 (100) | |
| Age at diagnosis | ||||
| Mean ± SD, years | 59.6 ± 8.4 | 57.0 ± 7.8 | 62.0 ± 8.3 | |
| <59 years | 196 (46.4) | 120 (59.1) | 76 (34.7) | |
| ≥59 years | 226 (53.6) | 83 (40.9) | 143 (65.3) | <1 × 10−5 |
| Gender | ||||
| Male | 339 (80.3) | 164 (80.8) | 175 (80.0) | |
| Female | 83 (19.7) | 39 (19.2) | 44 (20.0) | 0.82 |
| Tumor site | ||||
| Oropharynx | 163 (38.6) | 106 (52.2) | 57 (26.0) | |
| Hypopharynx | 53 (12.6) | 38 (18.7) | 15 (6.9) | |
| Larynx | 206 (48.8) | 59 (29.1) | 147 (67.1) | <1 × 10−5 |
| Clinical stage | ||||
| I | 45 (10.7) | 2 (1.0) | 43 (19.6) | |
| II | 87 (20.6) | 5 (2.5) | 82 (37.5) | |
| III | 74 (17.5) | 38 (18.7) | 36 (16.4) | |
| IVA/B | 216 (51.2) | 158 (77.8) | 58 (26.5) | <1 × 10−5 |
| T stage | ||||
| 1–2 | 214 (50.7) | 59 (29.1) | 155 (70.8) | |
| 3–4 | 208 (49.3) | 144 (70.9) | 64 (29.2) | <1 × 10−5 |
| N stage | ||||
| 0 | 187 (44.3) | 33 (16.3) | 154 (70.3) | |
| 1–3 | 235 (55.7) | 170 (83.7) | 65 (29.7) | <1 × 10−5 |
| Smoking status | ||||
| Never | 85 (20.1) | 46 (22.7) | 39 (17.8) | |
| Ever | 337 (79.9) | 157 (77.3) | 180 (82.2) | 0.214 |
| Alcohol consumption b | ||||
| Never | 97 (23.0) | 47 (23.1) | 50 (22.8) | |
| Ever | 322 (76.3) | 154 (75.9) | 168 (76.7) | 0.914 |
| Treatment modality | ||||
| RT alone | 219 (51.9) | 219 (100) | ||
| Concurrent CHRT | 131 (31.0) | 131 (64.5) | ||
| iCHT/RT | 32 (7.6) | 32 (15.8) | ||
| iCHT/concurrent CHRT | 40 (9.5) | 40 (19.7) |
RT + CHT, combination treatment; RT, radiotherapy; iCHT, induction chemotherapy; CHRT, chemoradiotherapy; SD, standard deviation. a Chi-square p-value for comparison between treatment subgroups. b Data not available for three patients.