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The hydroquinone moiety of PAH is essential to increase doxorubicin efficacy. (A) PAH precursors and analogues. (B) Effect of PAH precursors and analogues on dxr cytotoxicity. Cell viability was measured after treatment with increasing concentration of dxr in the presence of DMSO or 20 µM sPAH (10), PAH precursors 8 and 9, or PAH analogues 11, 12, and 13 in MeWo cells. Dxr-IC50 values calculated in the presence of sPAH or PAH analogue 13 are presented.
