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Synthetic panicein A hydroquinone (sPAH) increases doxorubicin cytotoxicity against several melanoma cell lines. IC50s were calculated using GraphPad Prism 6 software. The mean ± SEM of 3 independent experiments are presented.
| Treatment | Dxr IC50 (µM) | ||
|---|---|---|---|
| MeWo | MeWo DxrR | A375 | |
| Dxr + DMSO | 141.5 ± 2.2 | 247 ± 49 | 41 ± 8.2 |
| Dxr + sPAH 20 µM | 1.1 ± 0.4 | 1.75 ± 1 | 0.6 ± 0.2 |
