Figure 5.

(a) Bright-field TEM image of MnO₂ nanosheets with scale bar 200 nm. Adapted with permission from [111]. (b) O₂ generation efficacy of MnO₂ nanosheets in H₂O₂ solution at different concentrations of Ce6@MnO₂-PEG (0, 25, and 50 µM). (c) The concentration-dependent T₁ relaxation rates and the longitudinal relaxivities (r1) of the composite measured at different pH 7.4 and 6.5. (d) T₁-weighted MR images of various concentrated Ce6@MnO₂-PEG nanocomposite at different pH values 7.4 and 6.5. Adapted with permission from [103]. (e) Increase in temperature observed at the tumor site of BALB/c nude mice bearing 4T1 tumor xenograft during NIR-triggered PTT treatment after intravenous injection of MnO₂-SPs nanosheets. (f) Digital photos of tumors excised from 4T1 tumor-bearing BALB/c nude mice after 16 days of intravenous injection followed by different treatments. (g) Tumor tissues of each group after PTT were stained by Antigen Ki-67 immunofluorescence (upper), TUNEL (middle), and H&E (bottom) (Scale bar: 100 µm). Adapted with permission from [51].