Table 3.
Gene Mutations Related to CLA and LEV Resistance of the 112 H. pylori Positive Samples
| Antibiotics | Sample Type | n/N (%) | Mutations | Percentage of Mutation |
|---|---|---|---|---|
| CLA | AS | 33/65 (50.8%) | A2143G | 33/33 (100%) |
| NS | 24/47 (51.1%) | A2143G | 24/24 (100%) | |
| LEV | AS | 23/65 (35.4%) | N87K | 15/23 (65.2%) |
| D91Gly | 7/23 (30.5%) | |||
| D91Y | 1/23 (4.3%) | |||
| NS | 14/47 (29.8%) | N87K | 9/14 (64.2%) | |
| D91Gly | 4/14 (28.6%) | |||
| D91Y | 1/14 (7.0%) | |||
| CLA + LEV | AS | 18/65 (27.7%) | A2143G + N87K | 11/18 (61.1%) |
| A2143G + D91Gly | 6/18 (33.3%) | |||
| A2143G + D91Y | 1/18 (5.6%) | |||
| NS | 4/47 (8.5%) | A2143G + N87K | 3/4 (75%) | |
| A2143G + D91Gly | 1/4 (25%) |
Abbreviations: A, adenine; AS, active strain; CLA, clarithromycin; D, aspartic acid; G, guanine; Gly, glycine; K, lysine; LEV, levofloxacin; N, asparagine; Y, tyrosine; NS, no strain (ie, no active H. pylori strain isolated from the sample).