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. 2020 Jun 5;12(6):1478. doi: 10.3390/cancers12061478

Figure 3.

Figure 3

In vitro drug screening. (A) Growth of meningioma cells in vitro as monolayer (upper panel) or as tumorspheres (lower panel). (B) Comparison of drug responses (IC50) between the primary and the recurrent tumors. Among the 60 drugs tested, 38 drugs exhibited an IC50 greater than 10 µM (in the grey area) and majority of them (27/38 = 71%) were found in the recurrent tumor. (C) List of the 12 drugs that were found to be cytocidal (cell viability < 15% at 10 micromolar) in either the primary (K29P-PC) or the recurrent (K29R-PC) or both (n = 8). (C) Summary of the in vitro drug screen. Scale bars: 50 mm. Abbreviations: IC50, half maximal inhibitory concentration; mm, micrometers; PC, primary culture.