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. 2020 Jun 5;12(6):1478. doi: 10.3390/cancers12061478

Figure 5.

Figure 5

In vivo validation of Panobinostat. (A) In vivo validation of the anti-tumor activities of Panobinostat in the recurrent PDOX model (K29R-PDOX). (B). Western blot analysis showing the time and dose changes induced by Panobinostat in vitro in cultured meningioma cells derived from the recurrent tumor (K29R-PC) cells. Note the induction of acetylation in histone H3 (acetyle-H3) and cleavage of PARP in cells treated for 48 hr at 0.5 µM. Abbreviations: patient derived orthotopic xenograft (PDOX); primary culture (PC); Poly (ADP-ribose) polymerase (PARP).