Table 1.

Parameter sets used in the model.

	${\mathit{g}}_{\mathit{M}8}$	${\mathit{g}}_{\mathit{l}}$	${\mathit{g}}_{\mathit{s}\mathit{d}}$	${\mathit{g}}_{\mathit{s}\mathit{r}}$	${\mathit{g}}_{\mathit{d}}$	${\mathit{g}}_{\mathit{r}}$	${\mathit{p}}_{\mathit{C}\mathit{a}}$	${\mathit{\tau }}_{\mathit{C}\mathit{a}}$	${\mathit{\tau }}_{\mathit{\delta }\mathit{V}}$	$\mathit{\delta }{\mathit{V}}_{\mathit{m}\mathit{i}\mathit{n}}$	$\mathit{\delta }{\mathit{V}}_{\mathit{m}\mathit{a}\mathit{x}}$
Set #	$\mathbf{m}\mathbf{S}/\mathbf{c}{\mathbf{m}}^2$						$\times {10}^4$	$\mathbf{m}\mathbf{s}$		$\mathbf{m}\mathbf{V}$
1	2.65	0.27	0.29	0.20	3.7	5.0	1.8	39,000	2167	−160	215
2	1.61	0.24	0.28	0.22	3.5	4.9	2.5	45,833	2083	−220	170
3	1.03	0.21	0.35	0.31	3.0	4.4	1.3	40,000	5167	−230	250
4	0.46	0.17	0.21	0.28	4.0	4.9	4.7	23,333	13,667	−250	110
5	0.58	0.16	0.20	0.28	3.9	4.7	5.2	23,333	16,000	−225	150
6	4.02	0.24	0.30	0.25	4.0	5.0	3.5	33,333	2167	−230	185
7	4.95	0.22	0.25	0.21	3.9	5.0	3.2	66,667	5833	−150	170
8	1.50	0.21	0.28	0.26	3.8	4.7	3.6	43,333	6667	−250	150
9	4.03	0.27	0.32	0.20	2.8	4.9	3.4	39,167	8333	−190	235
10	3.80	0.26	0.33	0.21	3.0	4.7	3.3	65,000	15,333	−220	250
11	3.69	0.18	0.21	0.23	2.5	3.4	4.6	40,833	11,667	−230	240
12	2.30	0.19	0.21	0.22	2.7	3.0	4.7	31,667	25,000	−230	250
13	3.11	0.20	0.21	0.20	2.4	2.3	5.5	40,000	13,833	−250	230
14	1.50	0.28	0.34	0.20	3.3	4.7	1.4	63,333	6833	−140	240
15	2.30	0.29	0.34	0.20	3.0	4.2	4.8	35,833	2333	−210	170
16	1.61	0.28	0.34	0.20	3.1	5.0	3.8	30,000	9000	−150	190
17	2.99	0.27	0.33	0.21	2.8	3.7	5.4	26,667	15,167	−140	170
18	1.84	0.23	0.25	0.20	4.0	5.0	5.8	31,667	10,417	−220	170
19	3.45	0.23	0.25	0.20	4.0	5.0	5.8	31,667	10,333	−250	250

g_M8, g_l, g_sd, g_sr, g_d and g_r are the maximum conductance densities of the respective ion currents (representative of the ion channel expression level). p_Ca is a parameter that controls how much the TRPM8 current contributes to an increase in [Ca²⁺]_i and channel desensitization. τ_Ca and τ_δV are the time constants for Ca²⁺ removal and for the desensitization process, respectively. δV_min and δV_max are the minimum and maximum values for TRPM8 V_1/2 displacement due to Ca²⁺-dependent desensitization (see [58,59]).