Table 2.
Inhibitors of the UPS.
| Inhibitor | Target | Reference |
|---|---|---|
| PYR-41 | E1 enzyme | [248,249] |
| MLN7243 | E1 enzyme | [250] |
| MLN4924 | E1 enzyme | [251] |
| Compound 4b | E1 enzyme | [252] |
| PYZD-4409 | E1 enzyme | [253] |
| Leucettamol A | E2 enzyme | [254] |
| Manadosterols A and B | E2 enzyme | [255] |
| CC0651 | E2 enzyme | [256] |
| Nutlins and derivatives, RITA, MI-219, Syl-155, MI-63, PRIMA-1, HLI98, HLI373, MEL23 and MEL24, ATSP-7041, NSC207895 | Mdm2/Mdmx/p53-mediated E3 ligase enzyme | [257,258,259,260,261,262,263,264,265,266,267] |
| Oridonin, SCF-12, ZL25, Compound A, Erioflorin, GS143, SMER3, TAME, Apcin | SCF E3 ligase | [268,269,270,271,272,273,274,275,276] |
| Bortezomib, CEP-18770, Carfilzomib (PR-171), ONX-0912, PR-047, MLN9708 and MLN2238 (Ixazomib), Marizomib (NPI-0052) | Proteasomal inhibitors | [277,278,279,280,281,282,283] |