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. 2020 Jun 21;21(12):4407. doi: 10.3390/ijms21124407

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Examples of patterns for BBB passage and brain accumulation. Brain/serum ratios have been corrected for vascular space by subtracting albumin brain/serum ratios. Left upper panel illustrates continuous linear uptake of SCC-90 exosomes. Right upper and left lower panels illustrate a plateau pattern as seen with primary T cell-derived and SCCVII-derived exosomes. Only the HaCaT exosomes (right lower panel) did not show an increase in the brain/serum ratio with time. The closed circles represent data points describing the linear portion of the curve; the open circles represent data points that departed from linearity. See Table 3 for statistics.