Table 3.
Pharmacokinetics for Whole Brain Uptake.
| Exosome | Ki | Vi | n * | r2 * | p< * | Pattern | %Par |
|---|---|---|---|---|---|---|---|
| J774A.1NC | 0.083 ± 0.017 | 1.72 | 12 | 0.710 | 0.001 | Linear | 92 ± 0.6 |
| NIH-3T3NC | 0.103 ± 0.040 | 1.11 | 10 | 0.455 | 0.05 | Plateau | 58 ± 3.7 |
| Primary T CellNC | 0.547 ± 0.116 | 3.19 | 10 | 0.736 | 0.005 | Plateau | 85 ± 2.9 |
| HaCaTNC | Flat | 58 ± 8.1 | |||||
| SCC-90C | 0.123 ± 0.015 | 2.40 | 12 | 0.866 | 0.001 | Linear | 77 ± 2.0 |
| PCI-30C | 0.057 ± 0.011 | 4.11 | 13 | 0.721 | 0.001 | Linear | 71 ± 2.9 |
| SCCVIIC | 0.162 ± 0.015 | 1.07 | 18 | 0.884 | 0.001 | Plateau | 93 ± 3.0 |
| MDA-MB-231C | 0.098 ± 0.034 | 3.66 | 10 | 0.514 | 0.05 | Plateau | 64 ± 4.5 |
| MEL526C | 0.091 ± 0.035 | 1.7 | 7 | 0.579 | 0.05 | Plateau | 72 ± 3.9 |
| KasumiC | 0.044 ± 0.013 | 3.3 | 11 | 0.568 | 0.01 | Linear | 79 ± 4.6 |
Ki in units of μL/g-min reported with SE; Vi in units of μL/g; %Par is the percent in parenchyma (capillary depletion), reported as mean with its standard error for an n = 3; * for linear portion of curve only. HaCaT did not show a statistically significant correlation between brain/serum ratios and time and its mean brain/serum ratio was 2.9 +/− 0.31 (n = 10). Superscript NC = noncancerous; superscript C = cancerous.