Figure 9.

Growth of MDA-MB-231 xenografts (A) and 4T1 homografts (B) treated with TOL compared to the growth of xenografts that received drug or stimulation alone or vehicle. A. Groups of mice (n = 8) were treated as indicated. None of the mice that were treated with TOL (red curve) met NIH criteria for humane endpoint euthanasia. Three mice in the drug-only group (brown curve), 2 in the stim-only group (blue curve) and 2 in the vehicle-only group (green curve) met humane endpoint criteria and had to be sacrificed. B. The graph shows that the rate of growth of ectopic 4T1 homografts treated with TOL is significantly slower when compared to the growth of homografts that received drug or stimulation alone or vehicle. A one-way ANOVA revealed a main effect. * p < 0.05 compared to each of the controls by Tukey II post-hoc comparisons.