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Estrogen receptor isoforms and mutants found within ovarian cancers. (A) Estrogen receptor alpha isoforms identified in ovarian cancers. (B) Mutated versions of estrogen receptor alpha found in ovarian cancers. Mutations at positions 537 and 538 have been observed. (C) Estrogen receptor beta isoforms identified in ovarian cancers. AF1 = Activation function 1; DBD = DNA binding domain; AF2 = Activation function 2; LBD = Ligand binding domain.
