Table 3.
Mutational comparison between CTCs and corresponding tumor breast tissue.
| Pt | CTCs | Concordance CTC/Tissue | BC Tissue Mutations | ||
|---|---|---|---|---|---|
| (Number Cells/Reaction) | Mutations (OBcfRAv2) | Detectable by OBcfRAv2 and Custom Panel | Detectable Only by Custom Panel | ||
| 5 | 3 | TP53 c.1100 + 30A > T | yes | TP53 c.1100 + 30A > T |
ERBB2 p.Ile654Val ERBB2 p.Ile655Val ERBB2 p.Pro1170Ala |
| 7 | 3 | TP53 p.Arg213= | yes | TP53 p.Arg213= | PIK3CA p.Asn345Lys ERBB2 p.Ile655Val |
| 9 | 3 | not found | yes | not found |
PIK3R1 p.Met326Ile
ERBB2 p.Pro1170Ala |
| 10 | 2 | not found | no | TP53 p.Arg248Gln | |
| 2 | not found | ||||
| 4 | not found | ||||
| 12 | 5 | TP53 c.1100 + 30A > T | yes | TP53 c.1100 + 30A > T | ERBB2 p.Pro1170Ala |
| 18 | 3 | not found | no | TP53 p.Cys275Leufs | ERBB2 p.Pro1170Ala |
| 3 | not found | ||||
| 24 | 2 | TP53 c.1100 + 30A > T | partial |
TP53 p.Arg248Trp TP53 c.1100 + 30A > T |
ERBB2 p.Pro1170Ala |
| 5 | TP53 c.1100 + 30A > T | ||||
| 51 | 3 | PIK3CA p. Hys1047Arg | yes | PIK3CA p. Hys1047Arg | |
| 6 | PIK3CA p. Hys1047Arg | ||||