Table 2.
Overview of the Ago2-IP and Brunello results for the 47 miR-26b-5p targeting genes.
| Gene | Transcript ID | FC of IP/T Ratio | Brunello Screen | miR-26b-5p Binding Site ** | |||
|---|---|---|---|---|---|---|---|
| DG75 | ST486 | FC | p-Value * | CDS | 3′UTR | ||
| COPS2 | ENST00000388901 | 5.1 | 4.0 | −13.9 | 4.97 × 10−86 | 7mA1 | 7mA1 |
| EZH2 | ENST00000320356 | 2.3 | 2.2 | −9.4 | 3.87 × 10−45 | 7mA1 | 8m |
| KPNA2 | ENST00000330459 | 2.5 | 3.3 | −6.6 | 1.16 × 10−6 | 8m | |
| MRPL15 | ENST00000260102 | 2.2 | 2.7 | −6 | 5.03 × 10−43 | 7mA1 | |
| NOL12 | ENST00000359114 | 2.2 | 2.1 | −5.6 | 2.67 × 10−47 | 8m | 7mA1 |
| EIF4E | ENST00000505992 | 2.9 | 4.3 | −4.3 | 5.76 × 10−12 | ||
| TRAPPC4 | ENST00000533632 | 2.1 | 2.3 | −3.7 | 1.0 × 10−8 | 7mA1 | |
| ALG1 | ENST00000262374 | 2.3 | 2.5 | −3.2 | 0.042 | 7m8 | |
| FANCF | ENST00000327470 | 3.4 | 2.6 | −2.4 | 3.52 × 10−4 | 7mA1/8m | |
| B3GNT2 | ENST00000301998 | 3.1 | 2.9 | −1.9 | 1 | 8m | |
| MT2A | ENST00000245185 | 3.4 | 2.4 | −1.7 | 0.045 | ||
| NXT1 | ENST00000254998 | 2.3 | 2.3 | −1.5 | 1 | ||
| MT1B | ENST00000334346 | 2.3 | 2.2 | −1.4 | 1 | ||
| MSMO1 | ENST00000261507 | 2.3 | 2.5 | −1.4 | 1 | 8m | |
| PPP1CC | ENST00000335007 | 2.9 | 3.8 | −1.2 | 1 | 7mA1 | |
| MT1E | ENST00000306061 | 2.2 | 2.7 | −1.2 | 1 | ||
| MPV17L2 | ENST00000599612 | 2.6 | 2.5 | −1.2 | 1 | 8m | |
| RHOQ | ENST00000238738 | 2.8 | 2.5 | −1.2 | 1 | 7mA1/7m8/8m | |
| TBC1D7 | ENST00000379300 | 2.0 | 2.8 | −1.2 | 1 | 8m | |
| TMEM156 | ENST00000381938 | 3.0 | 2.8 | −1.1 | 1 | 8m | 7mA1 |
| REEP4 | ENST00000306306 | 4.6 | 4.1 | −1.1 | 1 | 7m8 | |
| ASB10 | ENST00000420175 | 2.1 | 3.4 | −1.1 | 1 | ||
| OSCP1 | ENST00000235532 | 2.9 | 2.4 | -1 | 1 | ||
| H3F3C | ENST00000340398 | 2.3 | 3.0 | -1 | 1 | ||
| PRMT3 | ENST00000331079 | 2.1 | 2.7 | 1 | 1 | 7mA1 | |
| ZDHHC6 | ENST00000369405 | 4.2 | 3.9 | 1 | 1 | 8m | |
| DIABLO | ENST00000650715 | 2.1 | 2.1 | 1.1 | 1 | 7mA1 | |
| TXNDC17 | ENST00000250101 | 2.5 | 2.1 | 1.1 | 1 | 7mA1 | |
| MGST1 | ENST00000396209 | 3.5 | 4.5 | 1.1 | 1 | ||
| MSRB2 | ENST00000376510 | 3.8 | 3.8 | 1.2 | 1 | 7mA1 | |
| FRAT2 | ENST00000371019 | 3.7 | 3.3 | 1.2 | 1 | 8m | |
| ADAM19 | ENST00000257527 | 2.4 | 2.1 | 1.3 | 1 | 8m | |
| PRKCD | ENST00000330452 | 4.2 | 3.1 | 1.3 | 1 | 8m | |
| ACBD5 | ENST00000396271 | 3.3 | 2.5 | 1.3 | 1 | 7mA1/8m | |
| ZNF410 | ENST00000555044 | 2.4 | 2.4 | 1.3 | 1 | 8m | |
| ACYP2 | ENST00000394666 | 2.4 | 2.6 | 1.4 | 1 | ||
| BID | ENST00000317361 | 2.7 | 3.6 | 1.6 | 1 | 8m | |
| SLC25A36 | ENST00000324194 | 2.3 | 2.3 | 1.6 | 1 | ||
| CRADD | ENST00000332896 | 2.0 | 2.4 | 1.6 | 1 | 8m | |
| POLR3G | ENST00000369314 | 2.4 | 3.9 | 1.7 | 1 | ||
| SAAL1 | ENST00000524803 | 2.2 | 2.3 | 1.7 | 0.984 | 7mA1/8m | |
| TMEM206 | ENST00000261455 | 3.0 | 4.2 | 1.8 | 6.96 × 10−4 | ||
| LINC00847 | ENST00000501855 | 2.8 | 2.9 | ||||
| LOC100294145 | N/A | 2.2 | 2.1 | ||||
| MT1L | ENST00000565768 | 2.8 | 2.3 | ||||
| XLOC_l2_008009 | TCONS_l2_00014564 | 2.5 | 2.9 | ||||
| lnc-C2orf81-2 | lnc-C2orf81-2:1–2 | 2.3 | 2.2 | 7m8/8m *** | |||
* Cut-off for the significantly depleted or enriched genes: adjusted p-value < 0.001. ** No miR-26b-5p binding sites were present in 5′-UTR. *** Binding sites in noncoding RNAs were listed in the 3′-UTR column. 7mA1 = 7mer-A1, 7m8 = 7mer-m8, 8m = 8mer, FC = fold change, and N/A = not available.