Table 4.

Treatment of BRPC/LAPC.

Quality of the Evidence	Clinical Recommendation	Strength of the Recommendation	References
Low	In patients with BRPC preoperative treatment could increase survival in comparison with immediate surgery	Weakly positive	[33,34,35,36,37,38,39]
Very Low	Chemotherapy may be considered as a first-choice option as initial therapy, as alternative to chemoradiotherapy in patients with LAPC	Weakly positive	[40]
Moderate	In patients with LAPC who are progression-free after systemic chemotherapy (with reference to the schemes used in advanced disease), consolidation chemoradiotherapy may be considered	Weakly positive	[41,42,43]

Abbreviations–BRPC: Borderline Resectable Pancreatic cancer; LAPC: Locally Advanced Pancreatic Cancer.