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The anti-metabolite drug 5-fluorouracil (5-FU). (a) Catabolism of 5-FU to triphosphate 5-fluorouridine (FUTP), 5-fluoro-2’-deoxyuridine monophosphate (FdUMP), and 5-fluoro-2’-deoxyuridine triphosphate (FdUTP). (b) Schematic of uptake and important metabolites of 5-FU and F10 mechanisms interfering with DNA and RNA replication.
