Table 1.

Subclassification of histological heterogeneity of Non-Small Cell Lung Cancer (NSCLC).

NSCLC Subtype	Percentage (% Over NSCLC Cases)	Characteristics	Ref.
Adenocarcinoma	40	Presents frequent histologic heterogeneity. Mainly affects the outer edges of the lung.	[10,19]
Squamous cell carcinoma	30	Centrally located in the larger bronchi of the lung. The incidence is linked with smoking more than for other NSCLC cancers.	[10,19]
Large cell carcinoma	10	Non-differentiated type of lung cancer that lacks the architecture of squamous or glandular differentiation. It usually affects the peripherical part of the lung.	[10,19]
Adenosquamous carcinoma	<5	It is a subtype presenting components of both adenocarcinoma and squamous cell carcinoma.	[10,19,20]
Sarcomatoid carcinoma	<1	Centrally located in the larger bronchi of the lung and the peripherical part of the lung. Hard to diagnose due to its unclear characteristics which are common to other cancer subtypes.	[10,19]