Table 3.
Hazard Ratios for Cardiovascular Mortality According to Systolic Blood Pressure Categories Among Participants with Different Glycemic Status
| SBP (mmHg) | n/Total | Event Rate/ 1000 Person-Years |
Unadjusted HR (95% CI) | Adjusted HR (95% CI) |
|---|---|---|---|---|
| Normoglycemiaa | ||||
| Per SD change | 2.16 (2.00, 2.33)* | 1.21 (1.07, 1.37)* | ||
| <100 | 11/1822 | 0.67 | 1.78 (0.87, 3.66) | 2.85 (1.29, 6.33)* |
| 100–109 | 16/5339 | 0.34 | 0.89 (0.47, 1.68) | 1.57 (0.80, 3.08) |
| 110–119 | 23/6775 | 0.38 | 1.00 | 1.00 |
| 120–129 | 48/4408 | 1.21 | 3.20 (1.95, 5.26)* | 1.66 (0.96, 2.86) |
| 130–139 | 42/2294 | 2.06 | 5.45 (3.28, 9.07)* | 1.73 (0.97, 3.10) |
| 140–149 | 29/1184 | 2.80 | 7.45 (4.31, 12.89)* | 1.85 (1.00, 3.41)* |
| ≥150 | 87/1354 | 7.64 | 20.40 (12.88, 32.30)* | 2.71 (1.56, 4.69)* |
| Prediabetesa | ||||
| Per SD change | 1.59 (1.45, 1.73)* | 1.17 (1.04, 1.32)* | ||
| <100 | 4/339 | 1.76 | 0.74 (0.26, 2.07) | 0.87 (0.31, 2.49) |
| 100–109 | 15/1195 | 1.82 | 0.77 (0.42, 1.39) | 0.97 (0.5, 1.85) |
| 110–119 120–129 130–139 140–149 ≥150 |
40/2392 42/2469 42/1832 32/1060 98/1398 |
2.38 2.43 3.10 4.15 9.33 |
1.00 1.02 (0.66, 1.57) 1.30 (0.84, 2.01) 1.74 (1.09, 2.77)* 3.91 (2.71, 5.65)* |
1.00 1.00 (0.62, 1.60) 0.83 (0.50, 1.37) 0.90 (0.53, 1.53) 1.57 (0.99, 2.49) |
| Diabetesb | ||||
| Per SD change | 1.37 (1.25, 1.51)* | 1.15 (1.03, 1.30)* | ||
| <100 | 11/175 | 10.14 | 2.14 (1.09, 4.20)* | 1.31 (0.61, 2.84) |
| 100–109 | 13/494 | 3.87 | 0.81 (0.43, 1.52) | 1.00 (0.51, 1.97) |
| 110–119 | 37/1119 | 4.86 | 1.00 | 1.00 |
| 120–129 | 51/1319 | 5.77 | 1.19 (0.78, 1.81) | 1.30 (0.81, 2.09) |
| 130–139 | 51/1191 | 6.22 | 1.26 (0.83, 1.92) | 0.98 (0.60, 1.61) |
| 140–149 | 38/772 | 6.98 | 1.43 (0.91, 2.24) | 1.18 (0.71, 1.96) |
| ≥150 | 104/1115 | 13.71 | 2.80 (1.93, 4.08)* | 1.66 (1.05, 2.63)* |
Notes: *P <0.05; aAdjusted for age, sex, race, education, smoke, body mass index, diastolic blood pressure, baseline cardiovascular disease, baseline cancer, baseline hypertension, dietary intake, total cholesterol, high-density lipoprotein cholesterol, estimated glomerular filtration rate, statin, antiplatelet drugs, and antihypertensive drugs; bAdjusted for age, sex, race, education, smoke, body mass index, diastolic blood pressure, baseline cardiovascular disease, baseline cancer, baseline hypertension, dietary intake, total cholesterol, high-density lipoprotein cholesterol, estimated glomerular filtration rate, statin, antiplatelet drugs, antihypertensive drugs, and antihyperglycemic drugs.
Abbreviations: SBP, systolic blood pressure; HR, hazard ratio; CI, confidence interval.