Figure 1.

Stress-mediated inducers of cellular senescence in cancer. Damage-associated senescence associated with cancer development can occur in cells of the immune system due to SASP released by tumor cells, after accumulation of DNA damage, after inflammatory insults such as ROS or mitochondrial dysfunction which also impacts ROS production, after radiotherapy damage and chemotherapy treatments in tumor cells and also as a result of oncogenic mutations. SASP, senescence-associated secretory phenotype; ROS, reactive oxygen species.