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. 2020 Jun 3;12(6):1453. doi: 10.3390/cancers12061453

Figure 2.

Figure 2

(a) Volcano plot showing the log2FC of gene expression and the statistical significance of the differential expression (DE) analysis performed between MCF-7 cells transfected with control or DSCAM-AS1-targeting LNA GapmeRs. In red are the upregulated genes, while in blue are the downregulated ones. The top first 20 significant DE genes are labeled. (b) Bar plot showing the expression log2FC of 10 DE genes whose expression was measured by qRT-PCR. Data from three biological replicates and p-value by T-test test: ***, p-value < 0.001; **, p-value < 0.01; *, p-value < 0.05. (c,d) Bar plot reporting the top 20 significantly enriched biological processes related to downregulated and upregulated genes, respectively. The number of genes per GO (gene ontology) term is shown and the color code is proportional to significance. (e) Venn Diagram showing the overlap between genes DE in this study and those DE upon ERα silencing [13]. (f,g) Top 20 enriched GO terms of overlapping DE genes showing concordant regulation are shown for genes upregulated (f) and downregulated (g) in both datasets.