Table 5.

Univariate and multivariate Cox Regression analysis.

	Univariate Analysis				Multivariate Analysis
	PFS		OS		PFS		OS
	HR (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Gender (Male vs. Female)	1.0 (0.8–1.4)	0.986	0.9 (0.7–1.2)	0.411	-	-	-	-
Histology (Colon/Sigmoid vs. Rectum)	1.2 (0.9–1.6)	0.267	1.2 (0.9–1.7)	0.172	-	-	-	-
PS ECOG (≥2 vs. 0–1)	2.6 (1.6–4.2)	<0.001	4.4 (2.8–6.9)	<0.001	1.6 (1.0–2.6)	0.04	3.7 (2.4–5.9)	<0.001
Age (≥70 vs. <70)	1.1 (0.8–1.4)	0.652	1.3 (1.0–1.8)	0.06	-	-	-	-
Grade (High vs. Low)	1.4 (0.6–3.4)	0.493	4.4 (1.8–11.0)	0.001	-	-	1.8 (0.7–5.1)	<0.001
KRAS	1.0 (0.8–1.4)	0.787	1.2 (0.8–1.6)	0.362	-	-	-	-
TLR2 196-to-174 del (homozygous mutant vs. others)	2.1 (1.2–3.9)	0.016	3.7 (2.4–5.9)	<0.001	2.2 (1.2–4.1)	0.013	2.1 (1.3–3.4)	0.003
TLR4-Asp299Gly (homozygous mutant vs. others)	1.2 (0.9–1.7)	0.259	2.3 (1.7–3.3)	<0.001	-	-	1.4 (1.0–1.9)	0.095
TLR4-Thr399Ile (homozygous mutant vs. others)	1.2 (0.9–1.7)	0.259	2.3 (1.7–3.3)	<0.001	-	-	1.4 (1.0–1.9)	0.095
TLR9-T1237C (homozygous mutant vs. others)	1.0 (0.7–1.4)	0.928	1.7 (1.3–2.3)	<0.001	-	-	1.1 (0.8–1.6)	0.336
TLR9-T1486C (homozygous mutant vs. others)	1.0 (0.7–1.4)	0.928	1.7 (1.3–2.3)	<0.001	-	-	1.1 (0.8–1.6)	0.336
TaqI (homozygous mutant vs. others)	1.2 (0.9–1.2)	0.783	2.2 (1.8–2.7)	<0.001	-	-	1.3 (1.0–1.6)	0.029
ApaI (homozygous mutant vs. others)	1.1 (0.9–1.3)	0.46	2.6 (2.1–3.1)	<0.001	-	-	1.6 (1.3–2.0)	<0.001
FokI (homozygous mutant vs. others)	1.1 (0.9–1.2)	0.768	2.2 (1.9–2.6)	<0.001	-	-	1.4 (1.1–1.8)	0.005
BsmI (homozygous mutant vs. others)	0.1 (0.9–1.3)	0.616	1.7 1.4–2.2)	<0.001	-	-	1.0 (0.7–1.6)	0.644