Table 1.
Discriminating metabolites between CD-fed and HFD-fed male mice.
| Decreased under HFD | Increased under HFD | |
|---|---|---|
| Liver (LI) |
1,5-Anhydro-d-sorbitol; l-Saccharopine; Indoxyl-sulfate; Imidazolelactic-acid; Methylhippurate; 3-Methylhistidine; Methionine; 2-Deoxyribose-5-phosphate; UMP; Inosine-5-monophosphate; GMP; 4-Guanidinobutyric-acid; 3-AMP/5-AMP; 4-Hydroxy-3-methoxyphenylglycol-sulfate; 3-Methylcrotonyl-glycine/N-Tiglylglycine; Guanine; l-Alanyl-l-proline; d-Glucosamine-6-phosphate; Glycerol-3-phosphate; Hydroxyphenylpyruvic-acid; Cytidine; ortho-Methylhippuric-acid/meta-Methylhippuric-acid/para-Methylhippuric-acid/Phenylacetylglycine; d-Fructose-1-phosphate/d-Fructose-6-phosphate/d-Mannose-6-phosphate/Galactose-1-phosphate/Glucose-1-phosphate/Glucose-6-PO4/Mannose-1-phosphate; Caprylolyglycine; UDP; Nervonic-acid; N-Acetyl-l-methionine; N-Isobutyrylglycine; 2-Oxobutyric-acid; N-Glycolylneuraminic-acid; 5-AMP/dGMP; Phosphonoacetic-acid; Guanosine-5-diphospho-d-mannose/Guanosine-5-diphosphoglucose; dGMP; Serine; Orotic-acid; Hexanoyl-glycine/N-Acetyl-d-allo-isoleucine/N-Acetyl-l-leucine; N-Acetyl-d-penicillamine/N-Acetyl-l-Methionine; Hexanoyl-glycine; Phosphoserine; Deoxyinosine; Uridine; Sebacic-acid; Guanosine-5-diphospho-l-fucose; 5-Aminolevulinic-acid/cis-4-hydroxy-d-proline/trans-3-Hydroxy-l-proline/trans-4-hydroxy-l-proline; Purine; Myristic-acid; N-Acetylneuraminic-acid; d-Pyroglutamic-acid; Muramic-acid; Leu-Pro; Pyrrole-2-carboxylic-acid; D-Arabinose |
3-Hydroxybutyric-acid; N-N-Dimethylglycine; Betaine; NAD; Taurine; 13-S-Hydroxyoctadeca-9Z-11E-dienoic-acid; Argininosuccinic-acid; 1-Methyladenosine; S-Adenosyl-homocysteine; Cyclic-ADP-ribose; dl-alpha-Hydroxystearic-acid; gamma-Linolenic-acid; β-Alanine; d-Threitol; Asparagine; 3-Ureidopropionic-acid; Quinolinic-acid; l-Glutamic-acid; N-Methyl-d-aspartic-acid; Stachydrine; l-Cysteinesulfinic-acid; l-Kynurenine; Propionylcarnitine; ADP; 2-O-Methylinosine; Riboflavin; Pyridoxamine-5-phosphate; Sphinganine; 3-Hydroxy-2-methyl-butanoic-acid/3-Hydroxypentanoic-acid; Perillic-acid; l-Cysteic-acid; d-Sphingosine; 2-Aminopyridine-3-carboxylic-acid; Phosphoenolpyruvic-acid; 2-O-Methylguanosine; Fumaric-acid/Maleic-acid; 3-Hydroxypicolinic-acid; Uracil; Xanthosine; Diglycolic-acid/Malic-acid; d-Mannitol-1-phosphate; Prostaglandin-A1; Carnitine; Prostaglandin-E1; Indolelactic-acid; 5-Aminoimidazole-4-carboxamide-1b-d-ribofuranoside; Nicotinic-acid; 2-Hydroxyhexadecanoic-acid; Xanthine; N6-N6-N6-Trimethyl-l-lysine; Arachidic-acid; Cytidine-5-diphosphocholine; 4-Pyridoxic-acid; d-Glyceric-acid; Aldosterone |
| Hypothalamus (HYP) | 1,5-Anhydro-d-sorbitol ; l-Saccharopine; 3-Methylhistidine |
3-Hydroxybutyric-acid; Argininosuccinic-acid; Pantothenic-acid; Tyrosine; dl-Tryptophan; Phenylalanine; Arginine; Tartaric-acid; Valine; Asparagine; Gly-Pro/Pro-Gly; 3-Aminosalicylic-acid; Leu-Pro |
| Whole olfactory bulb (WOB) | 1,5-Anhydro-d-sorbitol; l-Saccharopine; cis-5,8,11,14,17-Eicosapentaenoic-acid; cis-8,11,14-Eicosatrienoic-acid; Lysine; trans-4-hydroxy-l-proline; l-Homoserine/Threonine |
3-Hydroxybutyric-acid; gamma-Linolenic-acid; Pantothenic-acid; 3-Aminosalicylic-acid |
When a compound has several putative annotations, they are separated by a “/”. Bold characters indicate metabolites validated by MS/MS; italic characters indicate metabolites that were not validated by MS/MS; regular characters indicate metabolites for which annotation could not be specified by MS/MS or was not tested. Underlined metabolites were affected similarly by the HFD in all three tissues.