Figure 3.

General comparison of conventional and stereotactic SBRT-mimicking RIPF models. (A) Summary of conventional and SBRT-mimicking RIPF models. In the conventional RIPF model, a large volume of the lung is irradiated with a relatively low dose of radiation, and an abundance of radiobiological research data has been generated. In contrast, the SBRT-mimicking RIPF model mimics modern radiotherapy whereby there is local irradiation with high radiation doses. (B) Both the dose and fractionation of radiation contribute to the severity of radiation fibrosis. RIPF is known to be accelerated with a higher radiation dose per fraction. Therefore, the radiation dose is very important for the development of RIPF. Abbreviations: SBRT: Stereotactic body radiation therapy; RIPF: Radiation-induced pulmonary fibrosis