Table 2.
HOX genes with pronounced expression change between healthy and tumor tissues 1.
| Gene Name | Cancer Type | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| BRCA | ESCA | GBM | LAML | LGG | LIHC | LUSC | PAAD | STAD | |
| HOXA5 | 7.0 | ||||||||
| HOXA7 | 3.6 * | ||||||||
| HOXA9 | 3.7 | ||||||||
| HOXA10 | 6.2 | 3.4 | 4.3 | ||||||
| HOXB4 | 4.3 | ||||||||
| HOXB8 | 3.0 | ||||||||
| HOXB9 | 4.6 | 6.2 | |||||||
| HOXB13 | 6.8 | ||||||||
| HOXC4 | 5.5 | 3.5 * | |||||||
| HOXC6 | 5.9 | ||||||||
| HOXC8 | 3.2 | 3.5 | 4.6 | ||||||
| HOXC9 | 3.4 | ||||||||
| HOXC10 | 4.7 | 5.1 | 7.5 | ||||||
| HOXC11 | 3.7 | ||||||||
| HOXC13 | 4.3 | 5.1 | |||||||
| HOXD3 | 4.3 | ||||||||
| HOXD9 | 3.0 | ||||||||
| HOXD10 | 3.6 | ||||||||
| HOXD11 | 5.2 | ||||||||
1 The expression fold change of HOX genes with at least a 3-fold expression change between healthy and tumor tissues and with gene expression levels of at least 1 unit (RSEM normalized count, log2(x + 1) transformed) in healthy tissues. The cells marked * bold highlight the genes for which the Kaplan-Meier (KM) graph showed a significant correlation between gene expression and patients’ survival (analysis detailed below).