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. 2020 Jun 23;12(6):1661. doi: 10.3390/cancers12061661

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ROS level is upregulated upon BRAF and MEK inhibitor resistance. (A) ROS levels in WM-115 (parental, dabrafenib-resistant (DR), and trametinib- and dabrafenib-resistant (TDR) and WM-983 (parental, DR, and TDR) were measured by the DCFDA assay. (B) Basal superoxide levels in WM-115 (parental, DR, and TDR) and WM-983 (parental, DR, and TDR) cells were measured by the MitoSOX assay. * p < 0.05 versus parental cell lines. Statistical analysis by one way ANOVA.