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. 2020 May 30;12(6):1413. doi: 10.3390/cancers12061413

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation between FUT4 (CD15) expression levels and expression patterns of tumor microenvironment-related genes in 505 papillary thyroid carcinomas (PTCs) from the TCGA cohort. (A) The expression of FUT4 (CD15) mRNA is positively correlated with the infiltration level of immune and stromal cells based on the estimation by the ESTIMATE algorithm. The relative abundance of tumor infiltrating immune cells analyzed by the CIBERSORT algorithm (five cell types with positive correlation and five cell types with inverse correlation with FUT4 expression selected) (B), the expression level of immune checkpoints and cytolytic score (C), single sample enrichment score of MsigDB hallmark gene sets (10 positive and 10 inverse correlations with the selected FUT4 expression) (D), and epithelial mesenchymal transformation-associated genes (E).