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. 2020 May 26;12(6):1369. doi: 10.3390/cancers12061369

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genomic GLO1 deletion impairs metastasis in a SCID mouse model of malignant melanoma. (A) Melanoma cells (WT, B40_KO) were tail vein injected (five mice per group) followed by analysis of lung metastasis 21 d later. (B) Box plot depicts numeric analysis of metastases per lung. (C) Total lung specimens were obtained upon harvest [with field magnification (right panel) for visualization and counting of metastases]; left panels: GLO1_WT; right panel: GLO1_KO. (D) Representative lung tissue cross sections were visualized by H&E staining or (E) GLO1 immunostaining, absent from GLO1_KO tumor tissue [taken at 4 × (top) versus 20 × (bottom) magnification].