Table 1.

Mesenchymal stem cell-secreted proteins associated with oligodendroglial lineage regulation.

ID	Oligodendroglial Lineage-Promoting Factor	Gene Name	Description	Secretion Via/Localization	Reference
P07897	Aggrecan core protein	Acn	Inhibits oligodendrocyte myelination	SP 1	[30]
A0A140TA94	Chordin	Chrd	Promotes oligodendrogenesis From subventricular zone derived stem cells in vitro and in vivo	SP	[31]
Q9R1E9	Connective tissue growth factor	Ctgf	Negatively regulates myelination	SP	[32]
F1M8K0	Dystroglycan 1	Dag1	Intracellular portion of cleaved dag promotes oligodendroglial precursor cell proliferation/regulates myelin membrane production, growth, or stability	SP	[33,34]
A0A096P6L8	Fibronectin	Fn	Maintenance and proliferation of OPCs	SP	[35]
Q63772	Growth arrest-specific protein 6	Gas6	Protects oligodendrocytes from tumor necrosis factor-α-induced apoptosis	SP	[36]
P12843	Insulin-like growth factor-binding protein 2	Igfbp2	Negative effector of oligodendrocyte survival and differentiation	SP	[37]
F1M9B2	Insulin-like growth factor-binding protein 7	Igfbp7	Inhibits the differentiation of oligodendrocyte precursor cells via regulation of wingless-related integration site (Wnt) / β-catenin signaling	SP	[38]
P12843	Laminin subunit beta-2	Lamb2	Extracellular matrix proteins known to be important for myelination	SP	[39,40]
F1M798	Metalloendopeptidase	BMP1	Inhibits oligodendrogenesis	SP	[41]
P30120	Tissue inhibitor of metalloproteinase type 1	Timp-1	Promotes oligodendrocyte differentiation and central nervous system myelination	SP	[42,43]
P08721	Osteopontin	Spp1	Stimulates MBP synthesis and myelin sheath formation in vitro	SP	[44]
F7EPE0	Sulfated glycoprotein 1/prosaposin	Psap	Known as a myelinotrophic factor protecting myelinating glial cells	SP	[45,46]
Q9JI92	Syntenin-1	Sdcbp	Plays a role in OPC migration	UPS 2	[47]
M0R979	Thrombospondin 1	Thbs1	Reduces oligodendrogenesis	SP	[48]
A0A0G2K1L0	Tenascin c	Tnc	Inhibits OPC differentiation and myelination	SP	[49]

¹ SP: signal peptide; ² UPS: unconventional protein secretion.