Figure 5.

Correlation of MRI-derived tumor habitats with histological habitats. Stain density maps were used to generate histological habitat maps. The percent tumor area of each habitat was calculated for each histological section (panel (a)). Central imaging slices were selected from study endpoint (day 4 for BT-474 cohort, day 3 for MDA-MB-231 cohort) MRI data (panel (a)) and percent tumor volume of each habitat was calculated for each tumor’s central slice. The correlation was calculated between percent tumor volume (MRI) and percent tumor area (histology) for each habitat. For the BT-474 cohort (panel (b), left column), percent tumor volume of MRI-derived habitats showed a significant positive correlation with percent tumor area of histology-derived habitats for the HV-HC (r² = 0.74, p = 0.03) and LV-LC (r² = 0.70, p = 0.04) habitats. For the MDA-MB-231 cohort (panel (b), right column), percent tumor volume of MRI-derived habitats showed a significant positive correlation with percent tumor area of histology-derived habitats for the LV-HC (r² = 0.70, p = 0.04) and LV-LC habitats (r² = 0.73, p < 0.01).