Figure 3.

AML phosphoproteome in the FIRST RELAPSE group is enriched with cyclin-dependent kinases (CDKs) substrates. (a) Sequence motif analysis of the ± 31 amino acids flanking the differentially regulated phosphorylation sites (indicated with a black arrow) for the FIRST RELAPSE and DIAGNOSIS groups. (b) Kinase-substrate enrichment analysis (KSEA) of differentially regulated and unregulated phosphorylation sites. The kinase z-score (X axis) is the normalized score for each kinase (Y axis), weighted by the number of identified substrates.