Table 1.
Previous report of gene alteration in endometrium, endometriosis, endometriosis-associated ovarian cancer, and endometrial carcinoma.
| Gene | Function | Specimen | TCGA | |||
|---|---|---|---|---|---|---|
| Endometrium [48,51,52,103] | Endometriosis [47,48,103,104,105] | OCCC [76,78,99,100,103,106,107,108,109,110,111,112,113,114] | OEC [100,103,110] | Endometrial Carcinoma [60] | ||
| PIK3CA | PI3K/Akt/mTOR pathway | ● | ● | ● | ● | ● |
| PTEN | PI3K/Akt/mTOR pathway | ● | ● | ● | ● | ● |
| ERBB2 | PI3K/Akt/mTOR pathway | ● | ● | ● | ● | |
| PIK3R1 | PI3K/Akt/mTOR pathway | ● | ● | ● | ● | |
| KRAS | Ras/MAPK pathway | ● | ● | ● | ● | ● |
| NF1 | Ras/MAPK pathway | ● | ● | ● | ||
| ARID1A | SWI/SNF complex | ● | ● | ● | ● | |
| PPP2R1A | Serine/threonine-protein phosphatase | ● | ● | ● | ● | |
| MLH1 | Mismatch repair protein | ● | ● | ● | ● | |
| CTNNB1 | Wnt/β-catenin signaling pathway | ● | ● | ● | ||
| KMT2D | Histone methyltransferase | ● | ● | |||
| FBXW7 | Ubiquitin ligase | ● | ● | ● | ||
OCCC: Ovarian clear cell carcinoma, OEC: Ovarian endometrioid carcinoma, TCGA: The Cancer Genome Atlas.