Table 4.

Derived univariate and multivariable Cox-proportional hazard ratios (HR) of mortality for colon cancers.

Colon	Signet Ring vs. Non-Signet Ring		Signet Ring vs. Adenocarcinoma
HR (95% CI)	Univariate	Multivariable	Univariate	Multivariable
Signet Ring Histology	2.69 (2.58–2.79)	1.45 (1.40–1.51)	2.31 (2.22–2.40)	1.47 (1.41–1.53)
Age (per 10 years)	1.149 (1.144–1.154)	1.242 (1.237–1.248)	1.089 (1.083–1.094)	1.212 (1.205–1.218)
Gender (Female)	1.03 (1.02–1.05)	0.96 (0.95–0.97)	0.98 (0.97–0.99)	0.96 (0.95–0.97)
Race
Black	1.22 (1.20–1.24)	1.21 (1.19–1.23)	1.29 (1.26–1.31)	1.23 (1.21–1.25)
Other	0.91 (0.89–0.92)	0.93 (0.92–0.95)	0.92 (0.90–0.94)	0.94 (0.92–0.96)
Detection Stage
In Situ	0.42 (0.39–0.44)	0.39 (0.36–0.41)	0.53 (0.45–0.62)	0.43 (0.37–0.51)
Regional	3.01 (2.96–3.07)	3.13 (3.08–3.19)	2.48 (2.43–2.53)	2.70 (2.64–2.76)
Distant	17.5 (17.2–17.8)	16.6 (16.3–17.0)	14.2 (13.9–14.5)	14.4 (14.1–14.7)
Unstaged	8.8 (8.5–9.0)	4.32 (4.19–4.45)	6.66 (6.42–6.91)	3.40 (3.27–3.54)
Grade Differentiation
Moderate	1.73 (1.68–1.77)	1.25 (1.22–1.28)	1.37 (1.33–1.41)	1.17 (1.13–1.20)
Poor	3.18 (3.10–3.26)	1.80 (1.75–1.85)	2.34 (2.27–2.42)	1.65 (1.60–1.71)
Undifferentiated	3.19 (3.05–3.33)	1.98 (1.89–2.06)	2.37 (2.25–2.50)	1.73 (1.64–1.83)
Unknown	2.28 (2.22–2.35)	1.39 (1.35–1.43)	3.89 (3.75–4.03)	1.41 (1.36–1.46)
Surgery (Yes)	0.167 (0.165–0.170)	0.39 (0.38–0.40)	0.175 (0.172–0.178)	0.40 (0.39–0.41)
Radiotherapy (Yes)	2.14 (2.08–2.20)	1.08 (1.05–1.11)	1.83 (1.77–1.88)	1.08 (1.05–1.12)
Chemotherapy (Yes)	1.95 (1.93–1.98)	0.86 (0.85–0.87)	1.58 (1.56–1.60)	0.81 (0.80–0.82)

p < 0.05 relative to reference. Reference categories: Gender (Male), Race (White), Detection Stage (Localized), Grade differentiation (Well), Surgery (No), Radiotherapy (No), and Chemotherapy (No). CI, confidence interval.