Table 6.
Multivariable Adjusted Cox Proportional Hazards Models *‡ for AL Components with All-Cause and Cancer-Specific Mortality (N = 29,701).
| Allostatic Load Components | Continuous * | High vs. Low *† | Continuous * | High vs. Low *† |
|---|---|---|---|---|
| All-Cause mortality ‡ | Cancer mortality ‡ | |||
| Overall | ||||
| Deaths | 4622 | 4622 | 1237 | 1237 |
| CRP | 1.01 (1.01, 1.02) | 1.50 (1.41, 1.59) | 1.01 (1.01, 1.02) | 1.30 (1.16, 1.46) |
| Albumin | 0.60 (0.53, 0.67) | 1.44 (1.31, 1.59) | 0.80 (0.64, 1.00) | 1.12 (0.90, 1.39) |
| BUN | 1.03 (1.02, 1.04) | 1.46 (1.35, 1.57) | 1.01 (1.00, 1.02) | 1.12 (0.97, 1.28) |
| Total Cholesterol | 1.00 (1.00,1.00) | 1.00 (0.90, 1.11) | 1.00 (1.00, 1.00) | 0.95 (0.78, 1.16) |
| Creatinine | 1.37 (1.30, 1.43) | 2.10 (1.93, 2.28) | 1.14 (1.03, 1.25) | 1.19 (0.98, 1.45) |
| HDL | 1.00 (0.99, 1.00) | 1.13 (1.05, 1.21) | 1.00 (0.99, 1.00) | 1.07 (0.93, 1.23) |
| DBP | 1.00 (1.00, 1.00) | 1.15 (1.03, 1.28) | 0.99 (0.99, 1.00) | 0.82 (0.65, 1.03) |
| SBP | 1.01 (1.00,1.01) | 1.29 (1.21, 1.38) | 1.00 (1.00, 1.00) | 1.02 (0.90, 1.17) |
| WC | 1.01 (1.01, 1.01) | 1.06(0.99,1.14) | 1.00 (1.00, 1.00) | 0.91 (0.80, 1.04) |
| Blacks | ||||
| Deaths | 2055 | 2055 | 513 | 513 |
| CRP | 1.01 (1.01, 1.02) | 1.37 (1.24, 1.50) | 1.01 (1.01, 1.02) | 1.08 (0.90, 1.29) |
| Albumin | 0.52 (0.44, 0.61) | 1.57 (1.38, 1.78) | 0.74 (0.52, 1.05) | 1.12 (0.83, 1.50) |
| BUN | 1.03 (1.02, 1.04) | 1.57 (1.42, 1.75) | 1.01 (1.00, 1.02) | 1.13 (0.92, 1.39) |
| Total Cholesterol | 1.00 (1.00, 1.00) | 1.06 (0.92, 1.23) | 1.00 (1.00, 1.00) | 0.98 (0.73, 1.31) |
| Creatinine | 1.34 (1.27, 1.41) | 2.25 (2.00, 2.52) | 1.15 (1.04, 1.27) | 1.24 (0.95, 1.62) |
| HDL | 1.00 (0.99, 1.00) | 1.15 (1.03, 1.29) | 1.00 (0.99, 1.00) | 1.12 (0.89, 1.40) |
| DBP | 1.00 (1.00, 1.01) | 1.20 (1.05, 1.37) | 0.99 (0.98, 1.00) | 0.88 (0.65, 1.17) |
| SBP | 1.01 (1.01, 1.01) | 1.34 (1.22, 1.47) | 1.00 (1.00, 1.01) | 1.08 (0.89, 1.31) |
| WC | 1.01 (1.01, 1.01) | 0.98 (0.88, 1.08) | 1.00 (0.99, 1.00) | 0.89(0.73, 1.09) |
| Whites | ||||
| Deaths | 2607 | 2607 | 704 | 704 |
| CRP | 1.02 (1.02, 1.03) | 1.61 (1.48, 1.74) | 1.02 (1.01, 1.02) | 1.48 (1.27, 1.72) |
| Albumin | 0.68 (0.58, 0.80) | 1.32 (1.15, 1.53) | 0.84 (0.63, 1.13) | 1.15 (0.86, 1.54) |
| BUN | 1.03 (1.03, 1.04) | 1.37 (1.23, 1.52) | 1.00 (0.99,1.02) | 1.11 (0.93, 1.33) |
| Total Cholesterol | 1.00 (1.00, 1.00) | 0.95 (0.82, 1.09) | 1.00 (1.00, 1.00) | 0.93 (0.71, 1.21) |
| Creatinine | 1.45 (1.34, 1.58) | 1.93 (1.70, 2.19) | 1.08 (0.86, 1.36) | 1.11 (0.83, 1.48) |
| HDL | 1.00 (0.99, 1.00) | 1.11 (1.01, 1.21) | 1.00 (0.99, 1.00) | 1.04 (0.88, 1.24) |
| DBP | 1.00 (0.99, 1.00) | 1.06 (0.88, 1.27) | 0.99 (0.98, 1.00) | 0.74 (0.51, 1.08) |
| SBP | 1.00 (1.00, 1.01) | 1.25 (1.14, 1.37) | 1.00 (0.99, 1.00) | 0.98 (0.81, 1.17) |
| WC | 1.01 (1.01, 1.01) | 1.14 (1.04, 1.26) | 1.00 (1.00, 1.01) | 0.94 (0.79, 1.13) |
* Model adjusted for demographic covariates, including age, race (except in race stratified models), sex, education, income, smoking status, physical activity level, and alcohol consumption,.† High AL: ≥3 biomarkers above threshold. Low AL: <3 biomarkers above threshold. ‡ Results are presented as HRs and 95% CI. Bold text p-values are below the selected two-sided alpha of 0.05.