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. 2020 Jun 17;21(12):4325. doi: 10.3390/ijms21124325

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Therapeutic approaches to tackle KRAS mutant NSCLC in patients. Selected compounds and their targets are listed. CDK4/6: cyclin-dependent kinase 4/6; Chk1: checkpoint kinase 1; CRBN: cereblon; PROTAC: proteolysis-targeting chimeras; VHL: von Hippel–Lindau disease tumor suppressor; HSP90: heat shock protein 90; RAF: rat fibrosarcoma; MEK: mitogen-activated protein kinase kinase; PI3K: phosphoinositide 3-kinase; AKT: protein kinase B; mTOR: mechanistic target of rapamycin kinase; KRAS: Kirsten rat sarcoma viral oncogene homolog; FAK: focal adhesion kinase; ERBB: human epidermal growth factor receptor; PD-1: programmed cell death protein 1; PD-L: programmed cell death 1 ligand; MAPK: mitogen-activated protein kinase.