A-RAF	V-Raf murine sarcoma 3611 viral oncogene homolog 1
AKT	Protein kinase B
ALK	Anaplastic lymphoma receptor tyrosine kinase
AMPK	AMP-activated protein kinase
APC/C	Anaphase-promoting complex/cyclosome
ASK1	Apoptosis signal-regulating kinase 1
ASO	Antisense-oligonucleotide
B-RAF	V-Raf murine sarcoma viral oncogene homolog B
Bad	BCL2-associated agonist of cell death
BCL-XL	B-cell lymphoma-extra large
BCL2	B-cell lymphoma 2
BET	Bromodomain and extraterminal domain
BRCA	Breast cancer gene
C-RAF	V-Raf-1 murine leukemia viral oncogene-like protein 1
CDC25C	M-phase inducer phosphatase 3
CDK	Cyclin-dependent kinase
CDKN2A/B	Cyclin-dependent kinase inhibitor 2A/B
Chk1	Checkpoint kinase 1
CRISPR/Cas9	Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9
CSC	Cancer stem-like cell
CTLA-4	Cytotoxic T-lymphocyte-associated protein 4
DDR1	Discoidin domain receptor 1
EGFR	Epidermal growth factor receptor
ERK	Extracellular regulated kinase
FAK	Focal adhesion kinase
FDA	U.S. Food and Drug Administration
FGFR	Fibroblast growth factor receptor
FTI	Farnesyltransferase inhibitor
G12C	Glycine 12 to cysteine
G12D	Glycine 12 to aspartic acid
G12V	Glycine 12 to valine
GAP	GTPase-activating protein
GATA2	GATA-binding protein 2
GDP	Guanosine diphosphate
GEF	Guanine nucleotide exchange factor
GGTase I	Geranylgeranyltransferase I
GTP	Guanosine triphosphate
HER2–4/ERBB2–4	Human epidermal growth factor receptors 2–4
HLA	Human leukocyte antigen
HRAS	Harvey rat sarcoma viral oncogene homolog
HSP90	Heat shock protein 90
ICMT1	Isoprenyl carboxyl methyltransferase
IGF1R	Insulin-like growth factor 1 receptor
IKK	IkappaB kinase
IκB	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
JNK	c-Jun N-terminal kinase
KEAP1	Kelch-like ECH-associated protein 1
KRAS	Kirsten rat sarcoma viral oncogene homolog
LKB1	Liver kinase B1
MAP3K7	Mitogen-activated protein kinase kinase kinase 7
MAPK	Mitogen-activated protein kinase
MEK	Mitogen-activated protein kinase kinase
MHC II	Major histocompatibility complex class II
mTOR	Mechanistic target of rapamycin kinase
NF-κB	Nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells
NRAS	Neuroblastoma rat sarcoma viral oncogene homolog
NSCLC	Non-small-cell lung cancer
ORR	Objective response rate
p53	Tumor protein p53
p90RSK	p90 ribosomal S6 kinase
PARP	Poly(ADP-ribose)polymerase
PD-1	Programmed cell death protein 1
PD-L1	Programmed cell death 1 ligand 1
PDX	Patient-derived xenograft
pERK	Phosphorylated ERK
PFS	Progression-free survival
PI3K	Phosphoinositide 3-kinase
PLD1	Phospholipase D1
PLK1	Polo-like kinase 1
PROTAC	Proteolysis-targeting chimera
PTEN	Phosphatase and tensin homolog
PTPN11	Protein tyrosine phosphatase non-receptor type 11
RAC	Ras-related C3 botulinum toxin substrate 1
RAF	Rat fibrosarcoma
RAL	Ras-like protein
RALGDS	Ral guanine nucleotide dissociation stimulator
RBD	RAS-binding domain
RCE1	RAS-converting enzyme 1
RET	RET proto-oncogene
RHOA	Ras homolog family member
RNAi	RNA interference
ROCK2	Rho-associated coiled-coil containing protein kinase 2
ROS	Proto-oncogene tyrosine-protein kinase ROS
RTK	Receptor tyrosine kinase
SNAIL2	Snail family transcriptional repressor 2
SRC	V-Src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
STK11	Serine/threonine kinase 11
STK3	Serine/threonine-protein kinase 3
TBK1	TANK binding kinase 1
TCA	Tricarboxylic acid cycle
TCR	T cell receptor
Th17	T helper 17
TIAM1	T lymphoma invasion and metastasis-inducing protein 1
Tim-3	T cell immunoglobulin mucin-3
TKI	Tyrosine kinase inhibitor
TPX2	Targeting protein for Xklp2
Treg	Regulatory T cells
ULK1	Unc-51-like autophagy activating kinase 1
VHL	von Hippel–Lindau disease tumor suppressor
WT1	Wilms tumor 1