| NSCLC | non-small-cell lung cancer |
| ErbB | erythroblastic oncogene B |
| EGFR | epidermal growth factor receptor |
| PTEN | phosphatase and tensin homolog |
| PI3K | phosphoinositide 3-kinases |
| MEK | mitogen-activated protein kinase kinase |
| ERK | extracellular signal-regulated kinases |
| TKIs | tyrosine kinase inhibitor |
| RTKs | receptor tyrosine kinases |
| MET | mesenchymal–epithelial transition factor |
| HGFs | hepatocyte growth receptors |
| IGFRs | insulin-like growth factors receptors |
| FGFRs | fibroblast growth factor receptors |
| VEGFRs | vascular endothelial growth factor receptors |
| MET | tyrosine-protein kinase Met |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| HGF | hepatocyte growth factor |
| FGFR | fibroblast growth factor receptors |
| JAK | Janus kinase |
| MAPK | mitogen-activated protein kinase |
| SPRY4 | Protein sprouty homolog 4 |
| VEGF | Vascular endothelial growth factor |
| PJA2 | E3 ubiquitin-protein ligase Praja2 |
| SNAIL2 | Sal-like protein 2 |
| RR | response rate |
| ORR | objective response rate |
| PFS | Progression Free Survival |
| mPFS | median PFS |
| OS | overall survival |
| mOS | median OS |
| DCR | Disease Control Rate |
| FDA | Food and Drug Administration |
| ILD | Interstitial lung disease |
| QTc | QT interval corrected for heart rate |
| CNS | central nervous system |
| EGFR-TFs | EMT-inducing transcription factors |