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. 2020 Jun 15;12(6):1587. doi: 10.3390/cancers12061587
NSCLC non-small-cell lung cancer
ErbB erythroblastic oncogene B
EGFR epidermal growth factor receptor
PTEN phosphatase and tensin homolog
PI3K phosphoinositide 3-kinases
MEK mitogen-activated protein kinase kinase
ERK extracellular signal-regulated kinases
TKIs tyrosine kinase inhibitor
RTKs receptor tyrosine kinases
MET mesenchymal–epithelial transition factor
HGFs hepatocyte growth receptors
IGFRs insulin-like growth factors receptors
FGFRs fibroblast growth factor receptors
VEGFRs vascular endothelial growth factor receptors
MET tyrosine-protein kinase Met
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
HGF hepatocyte growth factor
FGFR fibroblast growth factor receptors
JAK Janus kinase
MAPK mitogen-activated protein kinase
SPRY4 Protein sprouty homolog 4
VEGF Vascular endothelial growth factor
PJA2 E3 ubiquitin-protein ligase Praja2
SNAIL2 Sal-like protein 2
RR response rate
ORR objective response rate
PFS Progression Free Survival
mPFS median PFS
OS overall survival
mOS median OS
DCR Disease Control Rate
FDA Food and Drug Administration
ILD Interstitial lung disease
QTc QT interval corrected for heart rate
CNS central nervous system
EGFR-TFs EMT-inducing transcription factors