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. 2020 Jun 21;12(6):1643. doi: 10.3390/cancers12061643

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed models for myoferlin involvement in mitochondrial dynamics. Model A describes the functional interaction between mitofusins and myoferlin. Myoferlin interacts with mitofusin and participates, as a positive regulator, to mitochondrial fusion. Myoferlin depletion reduces efficiency or inhibits the mitofusin-mediated mitochondrial fusion. Model B depicts the mitofusin sequestration by myoferlin impairing the ER-mitochondria tethering and subsequent fission. Myoferlin silencing results in the stabilization of the ER-mitochondria tethering by mitofusin interaction allowing ER wrapping and DRP1 recruitment. Designed with Servier Medical Art (https://smart.servier.com) licensed under a Creative Commons Attribution 3.0 Unported License.