Table 1.

Study population characteristics.

	T1a n (%)	T1b without AC Involvement n (%)	T1b with AC Involvement n (%)	p-Value (* Statistically Significant)
Number of patients	22 (30)	5 (7)	47 (63)
Male gender	21 (95.5)	4 (80.0)	42 (89.4)	0.405
Age at diagnosis
<50 years	0	1 (20.0)	4 (8.5)	0.56
50–65 years	5 (22.7)	3 (60.0)	19 (40.4)
>65 years	17 (77.3)	1 (20.0)	24 (51.1)
Charlson comorbidity index (median (IQR))	3 (2–5)	2 (2–2)	3 (2–4)	0.049 *
Smoking habit
Yes	13 (59.1)	3 (60.0)	31 (66.0)	0.267
No	8 (36.4)	1 (20.0)	8 (17.0)
Missing data	1 (4.6)	1 (20.0)	8 (17.0)
Alcohol abuse
Yes	3 (13.6)	1 (20.0)	8 (17.0)	0.495
No	18 (81.8)	3 (60.0)	31 (66.0)
Missing data	1 (4.6)	1 (20.0)	8 (17.0)
Disease characteristics
Tumor location
Free margin	19 (86.4)	2 (40.0)	29 (61.7)	0.015 *
Superior aspect	3 (13.6)	3 (60.0)	8 (17.0)
Inferior aspect	0	0	10 (21.3)
Treatment
Type of treatment
Transoral laser microsurgery (TLM)	20 (90.9)	0	16 (34.0)	<0.001 *
Radiotherapy (RT)	2 (9.1)	5 (100.0)	31 (66.0)
Resection margin
Negative	17 (85.0)	-	12 (75.0)	0.530
Positive superficial, single	1 (5.6)	-	0
Positive superficial, multiple	0	-	1 (6.3)
Positive deep, single	0	-	1 (6.3)
Positive deep, multiple	0	-	1 (6.3)
Missing data	2 (10.0)		1 (6.3)
Post-treatment complications
No	15 (68.2)	2 (40.0)	35 (74.5)	0.249
Yes	7 (31.8)	3 (60.0)	12 (25.5)
Dysphagia	2 (9.1)	1 (25.0)	6 (12.8)
Dysphonia	0	1 (25.0)	0
Dyspnea	0	1 (25.0)	0
Stenosis	0	0	1 (2.1)
Granuloma	5 (22.7)	0	1 (2.1)
Adjuvant RT
No	21 (95.5)	5 (100.0)	33 (70.2)	0.83
Yes	0	0	5 (10.6)
Missing data	1 (4.6)	0	9 (19.2)