Table 2.
Distribution of likely deleterious variants among the three tumor types.
| Names | Total | Elements |
|---|---|---|
| INETs PDACs PNETs | 10 | CASC5 PAX7 ATRX NFKB2 HNF1A APC STK11 TSHR CREBBP RNF213 |
| PDACs PNETs | 11 | ARID2 MTOR COL1A1 MLL2 KAT6B BCL9 BLM FN1 NOTCH2 MSH6 ATM |
| INETs PDACs | 1 | ERBB4 |
| INETs PNETs | 2 | MLL3 LPHN3 |
| PDACs | 28 | EP400 CYP2D6 KRAS ABL2 BCL2 PTPRT TP53 RET KDM5C TET2 ING4 PER1 SMAD4 BCL6 PALB2 NPM1 NUP98 CDKN2A ERG BAP1 MET GATA1 PRDM1 ATR RNASEL FANCG PLEKHG5 KLF6 |
| PNETs | 34 | FGFR3 AURKB CDH1 FLI1 CKS1B CYP2C19 SMO UBR5 TNFAIP3 SOCS1 NTRK1 TNK2 MITF EPHA3 ARID1A MEN1 PIK3CG MLL VHL MAP2K1 MYD88 SF3B1 RPS6KA2 CSF1R BCR RUNX1T1 PRKDC TFE3 JAK3 AR PMS1 ESR1 DAXX NIN |
| INETs | 11 | FLT4 GDNF NOTCH1 SMARCA4 ZNF521 ITGB2 EP300 PTCH1 FLT3 BIRC3 TSC2 |
PNET—Pancreatic neuroendocrine tumor, PDAC—pancreatic ductal adenocarcinoma, INET—intestinal neuroendocrine tumor.